|
KMID : 0377619760300020245
|
|
Korean Jungang Medical Journal
1976 Volume.30 No. 2 p.245 ~ p.249
|
|
|
An Electron Microscopic Study on the Lysosomal Changes After Long-Term Carbon Tetrachloride Administration
|
|
|
|
|
Abstract
|
|
|
It is an well established fact that the long term administration of carbon tetrachloride to the experimental animal may cause hepatocellular degeneration which may advance to liver cirrhosis and occasionally even to liver cancer. However, there are not so much reports about the electron microscopic change of various organells in the cytoplasm of hepatocytes, and nearly no reports about the relationship between these structural alterations and functional change.
Among the various changes in hepatocytes of the rats of Spraque Dowley which was treated with carbon tetrachloride for long term, the authors studied especially the change in lysosome which has close relationships with the intracellular digestive process.
The following results were obtained:
1) The lysosomes of normal hepatocytes were very similar with those observed by other investigators.
2) Generally, the lysosomes of hepatocytes under long term administration of carbon tetrachloride was increased in number and particularly remarkable around the golgi complex and bile canaliculi.
3) There were found some differences in the content of increased lysosomes due to carbon tetrachloride and it was appreciated as a periodical differences of secondary lysosomes which were formed by union of autophagosome and primary lysosome.
4) Considering the fore mentioned results, the increase of lysosomes caused by the administration of carbon tetrachloride seemed to have close relationships with autophagocytosis.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|